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Cat's Claw / Una da Gato - Uncaria tomentosa (C-Med 100)


Cancer:
1998 Oct Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.
2000 Jul Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection.
2006 Mar Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
2006 Mar Proapoptotic effect of Uncaria tomentosa extracts
2006 Sep Medicinal plants from Peru: a review of plants as potential agents against cancer.
2007 Apr Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines.
2007 Sep Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells.
2007 Nov Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells.

Marrow Recovery: (C-Med 100 better than Neupogen? (GCS-F))
2000 Apr Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.
2003 Jan C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo.

AntiViral:
2008 Mar Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2.

AntiMicrobial:
2007 Mar Antimicrobial activity of Uncaria tomentosa against oral human pathogens.

DNA Repair / Immune Function:
2000 Feb Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.
2001 Jul DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study.
2001 Jul Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100.
2005 Apr Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements.
2007 Jul A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidants.

Skin:
2006 Mar A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin

Anti-inflamatory:
1998 Sep Antiinflammatory actions of cat's claw: the role of NF-kappaB.
2001 Sep Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis.
2002 May Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.
2007 Feb Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis.

How it works:
2002 May Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.
2003 Dec An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
2005 Jan Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100.
2005 Jan Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity.
2005 Jan An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid.
2006 Sep Changes in chromosome structure, mitotic activity and nuclear DNA content from cells of Allium Test induced by bark water extract of Uncaria tomentosa (Willd.) DC.
2006 Dec Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40).
2007 Mar The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation.
2007 Sep Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) D. C. cell suspension cultures via oxidative burst.

Cytokine Stimulation:
1999 Feb Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (uña de gato)
2007 Jan Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha.

Review:
2005 Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis.
MD Anderson Cat’s claw, uña de gato, uncaria tomentosa, uncaria guianensis, saventaro, C-Med-100®, Activar AC-11®
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