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Supplements, Research, Herbal Regimen

Peer reviewed journal research preferred (PubMed) see: Google Scholar Other Resources: NCCAM Clinical Trial Directory, Complimentary Medicine Search Evidence Based CAM, Oregon State University, Sloan Kettering, Creighton University, NCCAM Herbs, HerbMed, Sigma-Aldrich

	Purpose, Method, Dose Log, Supply

FeverFew? (parthenolide) (effective against AML stem cells?)

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2008 Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
2004 Oct The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
#2 Blood: (The long and winding road may be getting shorter)
#3 Blood: (An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells)
#4 Blood: (Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data)
#5 Blood: (Targeting LSCs: powering an old tool)
#6 Apoptosis: (Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity.)
#7 Best Practice and Research Clinical Haematology: (The leukemic stem cell)
#7 (same as directly above in a free format)
#8 Expert-Opin-Biol-Ther.: (Feverfew: weeding out the root of leukaemia.)
Dosage: Variations in parthenolide content and daily dose of feverfew products.
Integrative Medicine: Kettering
Delivery: Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer
Researcher: Dr. Craig Jordon - University of Rochester
Parthenolide Salt: Tested by University of Kentucky
New Drug: Medical News: New Leukemia Drug Stems From Feverfew
Trial: Clinical Trial (in England - only for consenting adults)
Bio-Availablilty:Transport of parthenolide across human intestinal cells (caco-2)
Dissolution:Challenges with Dissolution testing and Quality Assessment for Commercial FeverFew Products
Testing:Voltammetric determination of parthenolide in spiked human plasma and urine.
****Important facts about Parthenolide
Fact: (clotting reduction)
Fact: Depletes Glutathione ie. can be inhibited by N-Acetyl Cysteine (a precursor to glutathione):
Oxidative Stress-mediated Apoptosis (enhanced by L-buthionine-[S,R]-sulfoximine)
Cystic Fibrosis?: Parthenolide Inhibits I?B Kinase, NF-?B Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice
Sepsis?: Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis*.
Endotoxic shock?: Parthenolide, an Inhibitor of the Nuclear Factor-B Pathway, Ameliorates Cardiovascular Derangement and Outcome in Endotoxic Shock in Rodents

Crosses the Blood/Brain Barrier:
2006 Dec Parthenolide induces apoptosis in glioblastomas without affecting NF-kappaB.

Other Research:
NCCAM

Med Summary

Med Data:
  BM-RPIC -6/6
  Labs -7/7
  H Labs -7/11
  C Labs -7/11
  H Labs -7/16
  C Labs -7/16
  Head CT 7/18
  H Labs -7/21
  C Labs -7/21
  Head CT -7/21
  H Labs -7/26
  C Labs -7/26
  Head CT -7/28
  H Labs -8/04
  C Labs -8/04
  Head CT -8/04
  H Labs -8/18
  C Labs -8/18
  H Labs -9/04
  C Labs -9/04
  VNTR -9/04

Supplements:
  Purpose/Goals
  Methods
  Dosage Log
    Feverfew
    Tumeric
    Rieshi Mush.
    Una da Gato
    Onions
    Apples
    Green Tea
    Astragalus
    Milk Thistle
    Synbiotics
    Vitamin K2
    Vitamin E
    Fish Oil
    Parsley
    Burdock
    Echinacea
    Garlic
    Mangosteen
    Pau d'Arco

Work in Progress:
    Aloe Vera
    Soy
    Mistletoe
    Boswellia
    Vitamin D3
    Honokiol
    Pomegranate
    Goji
    Thunder Of God
    Others

Relapse Ramblings

Acute Myeloid
Leukemia

Infant Nutrition

Alternative
Therapy?