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Apoptosis, Review, Epigenetics, ROS Therapy, Blood-Brain, Cell Paths, Synergisms
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Burdock (Arctegenin, Arctiin)
Cancer Treatment:
1999 Nov Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation.
2003 Oct Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells.
2006 Feb Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.
2006 Feb Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells.

Cyclin D1:
2008 Mar Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.
2003 Dec Relationship between cyclin D1 and p21(Waf1/Cip1) during differentiation of human myeloid leukemia cell lines
2006 Feb Cyclin D1 expression in acute leukemia
1993 May Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Inflamatory Genes:
2008 Nov Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-kappaB in macrophages

Prostate Cancer:
2004 May Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells.