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Peer reviewed journal papers preferred (PubMed) see: Google Scholar
Other Resources: NCCAM Clinical Trial Directory, Complimentary Medicine Search
Evidence Based CAM, Oregon State University, Sloan Kettering, Creighton University, NCCAM Herbs, HerbMed, Sigma-Aldrich

Apoptosis, Review, Epigenetics, ROS Therapy, Blood-Brain, Cell Paths, Synergisms
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Reishi Mushrooms / Ganoderma lucidum
Components: triterpenoids, polysaccharides, lucidenic acid
Signaling: Akt/NFkappaB
Effects: Apoptosis, Differentiation, Phagocytosis, Cytokine/Immunoglobulin Production

Cancer Treatment:
1997 Mar The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes.
2002 The Immunomodulating Effects of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) (Aphyllophoromycetideae)
2002 Nov Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells.
2003 Jan Cancer Prevention and Treatment by Ganoderma, a Mushroom with Medicinal Properties
2003 Ganoderma Lucidum(Reishi) in Cancer Treatment
2004 Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling.
2004 May Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.
2004 Oct Immune receptors for polysaccharides from Ganoderma lucidum
2006 Jul Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.
2006 Aug Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1
2007 Nov Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.
2007 Ganoderma lucidum and its pharmaceutically active compounds.
2008 Apr Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells.
2008 Jun Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway.

Phagocytosis and Chemotaxis
2002 Jul Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway
2003 May Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidu
2007 May Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice
2007 Oct Phagocytosis and antigen presentation in dendritic cells
2004 Roles of PI3K in neutrophil function

Immunotherapy with Dendritic cells:
1992 Jul The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells.
2003 Apr Regulatory effects of Ganoderma lucidum polysaccharides on Cytotoxicity and mechanism of T-lymphocytes induced by dendritic cells (DC) in vitro
2005 Aug Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways.
2008 Jul Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function.
2008 Jan Immunotherapy with dendritic cells for cancer

Side Effects:
1990 Oct Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation

Other Reviews:
Sloan Kettering: Healthcare Professional Review
Peking University: Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum