Supplements, Research, AML Herbal Regimen
Tumeric (curcumin) (Thank You Margaret!)
Curcumin: from ancient medicine to current clinical trials.
Clinical study on the effect of curcumin on cell cycle proteins and regulating proteins of apoptosis in acute myelogenous leukemia
Mechanisms of proapoptotic properties of curcumin in chronic and acute myeloid leukemia
Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells.
Study on circumen-oligonucleotide conjugate as probable anti-cancer agent
Anticancer potential of curcumin: preclinical and clinical studies.
Induction of apoptosis by curcumin and its implications for cancer therapy.
Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis
Multiple Molecular Targets in Cancer Chemoprevention by Curcumin
New mechanisms and therapeutic potential of curcumin for colorectal cancer.
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells.
Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin.
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.
Modulatory Effects of Curcumin and Curcumin Analog on Circulatory Lipid Profiles During Nicotine-Induced Toxicity in Wistar Rats
Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Molecular targets of curcumin.
Opposing effects of curcuminoids on serum stimulated and unstimulated angiogenic response.
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
(Histone acetyltransferase (HAT) and histone deacetylase (HDAC))
Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy
Apoptotic pathways activated by histone deacetylase inhibitors: implications for the drug-resistant phenotype.
Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation.
Cancer Cells Become Susceptible to Natural Killer Cell Killing after Exposure to Histone Deacetylase Inhibitors Due to Glycogen Synthase Kinase-3–Dependent Expression of MHC Class I–Related Chain A and B
Histone deacetylase inhibitors.
Curcumin-induced histone hypoacetylation: the role of reactive oxygen species.
Curcumin is an inhibitor of p300 histone acetylatransferase.
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.
Small molecule modulators in epigenetics: implications in gene expression and therapeutics.
Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer.
Histone deacetylase inhibitors as novel anticancer therapeutics
(an good effect dampened by Curcumin?)
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B).
A Report On Curcumin's Anti-Cancer Effects
Curcumin - developing a following in American hospitals
Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma.
Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.
Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine.
Curcuminoids form reactive glucuronides in vitro.
Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases.
Radioprotection and radiosensitization by curcumin.
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.
Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer.
Other Research and Analysis:
#1 M.D. Anderson FAQ
#2 M.D. Anderson - Natural Standard
#3 Oregon State University: Linus Pauling Institute
#4 Sloan Kettering
#5 NCCAM Herbs