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Green Tea (Catechins / EGCG / Polyphenol)


Green Tea Green Tea and Leukemia:
1997 Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia.
1998 Growth inhibition of leukemic cells by (-)-epigallocatechin gallate, the main constituent of green tea.
2001 Jun Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis.
2004 Mar VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia.
2005 Mar Catechin, a green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo.
2006 Jun Natural products and the treatment of leukemia.
2006 Oct Induction of apoptosis via the modulation of reactive oxygen species (ROS) production in the treatment of myeloid leukemia.

Green Tea and Cancer:

1999 Mar Green tea polyphenols and cancer: biologic mechanisms and practical implications.
2003 Mar Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis.
2003 Dec Cancer prevention by tea polyphenols is linked to their
direct inhibition of antiapoptotic Bcl-2-family proteins.

2005 Aug Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species.
2006 Dec Green tea polyphenol epigallocatechin-3-gallate suppresses rat hepatic stellate cell invasion by inhibition of MMP-2 expression and its activation
2007 May A Novel Prodrug of the Green Tea Polyphenol (–)-Epigallocatechin-3-Gallate as a Potential Anticancer Agent
2007 Jul Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
2007 Apr (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: Inhibition of p44/p42 MAP kinase activation

Green Tea Crossing/Protecting the Blood-Brain Barrier:
2002 Dec Uptake and metabolism of epicatechin and its access to the brain after oral ingestion
2006 Apr Long-Term Administration of Green Tea Catechins Improves Spatial Cognition Learning Ability in Rats1
2008 Dec The neuroprotective potential of flavonoids: a multiplicity of effect
2005 Apr (-)Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis

Green Tea and Skin:
2001 Feb Green tea polyphenol (–)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
2005 Jun Green tea and the skin

Green Tea and Inflamation:
1998 Jul Green Tea Polyphenols Block Endotoxin-Induced Tumor Necrosis Factor-Production and Lethality in a Murine Model

Liver benefits from Green Tea:
2004 Nov Effects of tea polyphenols on hepatic fibrosis in rats with alcoholic liver disease.
2005 Jun Epigallocatechin-3-gallate, a green-tea polyphenol, suppresses Rho signaling in TWNT-4 human hepatic stellate cells
2006 May The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells
2006 Oct Ameliorate Liver Fibrosis
2007 Dec Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride–induced hepatic fibrosis

Heart benefits from Green Tea:
EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats

Platelets:
Complex effects of different green tea catechins on human platelets

Green Tea and Fat cells (adipocytes):
#1 Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes.
#2 Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells
#3 The apoptotic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the Cdk2 pathway
#4 Epigallocatechin gallate-induced apoptosis does not affect adipocyte conversion of preadipocytes.

Green Tea and Breast Cancer:
Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo.

Benefits vs. Risks of Green Tea:
2007 Mar Possible Controversy over Dietary Polyphenols: Benefits vs Risks
2009 Feb Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.

Green Tea Drug Interactions (see Sloan Kettering below):
Adenosine: The caffeine content in green tea may inhibit the hemodynamic effects of adenosine (18).
Anticoagulants / Antiplatelets: Theoretically, consumption of large amounts of green tea (.5-1 gallon/day) may provide enough vitamin K to antagonize the effects of anticoagulants and antiplatelet agents, though this effect has not been reported in humans (29) (34).
Atropine: The tannin content in green tea may reduce the absorption of atropine.
Iron supplements: The tannin content in green tea may reduce the bioavailability of iron. Green tea should be taken either 2 hours before or 4 hours following iron administration.
Codeine: The tannin content in green tea may reduce the absorption of codeine (18).
Bortezomib: EGCG and other polyphenols in green tea can inhibit the therapeutic effect of bortezomib (Velcade®) and other boronic acid based proteasome inhibitors

Mechanisms of Green Tea:
2005 Mar The antifolate activity of tea catechins
2006 Jun Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans
2008 Feb http://www.ncbi.nlm.nih.gov/pubmed/17570133 Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG
2003 Feb Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo
2005 Feb Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
2003 Dec Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.
2009 Jan (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor
2008 Apr (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases

Other Research about Green Tea:
#1 Sloan Kettering
#2 Thorne Research
#3 NCCAM Herbs
#4 BC Cancer
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