Supplements, Research, AML Herbal Regimen
Cellular Demise - Many Ways To Go:
5/25/2009
This page all started from a discussion I was having with my friend Jeff.
about the role
ATP depletion plays in triggering apoptosis and/or eliminating chemo resistance.
I believe ATP depletion plays a
supporting, not necessarily primary role in cancer treatment.
I've been suggesting that constant usage of ATP depleting supplements inhibits apoptosis.
This is an attempt to organize some of the reasons, methods, and tools I use to achieve cancer cell destinations.
New research on
Jasmonates (plant hormones) show that they deplete ATP and direct towards
necrosis instead of apoptosis.
I haven't been able to obtain jasmonates, however something I
do have is
PawPaw which contains the most potent (
ATP depleting) annonaceous acetogenins.
I also use
Burdock
and
Dong Quai to push cancer cells over the
nutrient starvation edge.
These days (
see dosage log) I am coordinating these tools (PawPaw, Burdock, Dong Quai)
...with
ROS therapy agents (Green Tea, Curcumin, FeverFew, Garlic, Quercetin, Ellagic Acid, etc.)
...Differentiation Therapy agents (Rieshi Mushrooms, Curcumin, etc.)
...and Immune Modulating agents (Rieshi, Shitake, Maitake, Una da Gato, etc.)

It is fascinating how all these tools synergize, modulating cellular metabolism to
...help "decide" between
differentiation, and
apoptosis
...redirect cell death from apoptosis towards
necrosis
...or push towards
senescence (hopefully eventual phagocytosis)
...and promote or block
autophagy (option or distraction).
While it might be more elegant to shift gears
onto the apoptosis exit ...sometimes our only
option might be to pop the clutch in 4th,
kill the engine, and get towed off.
Antioxidents help choose between apoptosis and differentiation:
ATP depleting agents help choose between apoptosis and necrosis:
Senescense - another "fork in the road" (with risks?) (immune modulation ...end with phagocytosis)
Bcl-2 protein imbalance prevents apoptosis/necrosis/senescense (making Green Tea (EGCG) especially helpful)
p53 necessary for BOTH apoptosis and senescense pathways (thank you Quercetin)
Telomerase can prevent senescense signaling (but again - thank you Green Tea)
Questions re: using Green Tea during/after a transplant: engraftment inhibition? premature aging?
Do Stem Cells follow the same paths?