Supplements, Research, AML Herbal Regimen
Cellular Demise - Many Ways To Go:
This page all started from a discussion I was having with my friend Jeff.
about the role ATP depletion
plays in triggering apoptosis and/or eliminating chemo resistance.
I believe ATP depletion plays a supporting, not necessarily primary
role in cancer treatment.
I've been suggesting that constant usage of ATP depleting supplements inhibits apoptosis.
This is an attempt to organize some of the reasons, methods, and tools I use to achieve cancer cell destinations.
New research on Jasmonates (plant hormones)
show that they deplete ATP and direct towards necrosis instead of apoptosis
I haven't been able to obtain jasmonates, however something I do have
which contains the most potent (ATP depleting
) annonaceous acetogenins.
I also use Burdock
and Dong Quai
to push cancer cells over the nutrient starvation edge
These days (see dosage log
) I am coordinating these tools (PawPaw, Burdock, Dong Quai)
...with ROS therapy
agents (Green Tea, Curcumin, FeverFew, Garlic, Quercetin, Ellagic Acid, etc.)
...Differentiation Therapy agents (Rieshi Mushrooms, Curcumin, etc.)
...and Immune Modulating agents (Rieshi, Shitake, Maitake, Una da Gato, etc.)
It is fascinating how all these tools synergize, modulating cellular metabolism to
...help "decide" between differentiation
, and apoptosis
...redirect cell death from apoptosis towards necrosis
...or push towards senescence
(hopefully eventual phagocytosis)
...and promote or block autophagy
(option or distraction).
While it might be more elegant to shift gears
onto the apoptosis exit ...sometimes our only
option might be to pop the clutch in 4th,
kill the engine, and get towed off.
help choose between apoptosis and differentiation:
ATP depleting agents
help choose between apoptosis and necrosis:
Senescense - another "fork in the road" (with risks?) (immune modulation ...end with phagocytosis)
Bcl-2 protein imbalance prevents apoptosis/necrosis/senescense (making Green Tea (EGCG) especially helpful)
p53 necessary for BOTH apoptosis and senescense pathways (thank you Quercetin)
Telomerase can prevent senescense signaling (but again - thank you Green Tea)
Questions re: using Green Tea during/after a transplant: engraftment inhibition? premature aging?
Do Stem Cells follow the same paths?