Jaymun Foundation

Supplements, Research, AML Herbal Regimen

Peer reviewed journal papers preferred (PubMed) see: Google Scholar Other Resources: NCCAM Clinical Trial Directory, Complimentary Medicine Search Evidence Based CAM, Oregon State University, Sloan Kettering, Creighton University, NCCAM Herbs, HerbMed, Sigma-Aldrich

	Apoptosis, Review, Epigenetics, ROS Therapy, Blood-Brain, Cell Paths, Synergisms Delivery, Dose Logs, Disclaimer

Cellular Demise - Many Ways To Go:

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5/25/2009

This page all started from a discussion I was having with my friend Jeff. about the role ATP depletion plays in triggering apoptosis and/or eliminating chemo resistance. I believe ATP depletion plays a supporting, not necessarily primary role in cancer treatment. I've been suggesting that constant usage of ATP depleting supplements inhibits apoptosis. This is an attempt to organize some of the reasons, methods, and tools I use to achieve cancer cell destinations.

These days (see dosage log) I am coordinating these tools (PawPaw, Burdock, Dong Quai)
    ...with ROS therapy agents (Green Tea, Curcumin, FeverFew, Garlic, Quercetin, Ellagic Acid, etc.)
    ...Differentiation Therapy agents (Rieshi Mushrooms, Curcumin, etc.)
    ...and Immune Modulating agents (Rieshi, Shitake, Maitake, Una da Gato, etc.)

It is fascinating how all these tools synergize, modulating cellular metabolism to
    ...help "decide" between differentiation, and apoptosis
    ...redirect cell death from apoptosis towards necrosis
    ...or push towards senescence (hopefully eventual phagocytosis)
    ...and promote or block autophagy (option or distraction).

While it might be more elegant to shift gears
onto the apoptosis exit ...sometimes our only
option might be to pop the clutch in 4th,
kill the engine, and get towed off.

Antioxidents help choose between apoptosis and differentiation:

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ATP depleting agents help choose between apoptosis and necrosis:

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Senescense - another "fork in the road" (with risks?) (immune modulation ...end with phagocytosis)

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Bcl-2 protein imbalance prevents apoptosis/necrosis/senescense (making Green Tea (EGCG) especially helpful)

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p53 necessary for BOTH apoptosis and senescense pathways (thank you Quercetin)

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Telomerase can prevent senescense signaling (but again - thank you Green Tea)

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Questions re: using Green Tea during/after a transplant: engraftment inhibition? premature aging?

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Do Stem Cells follow the same paths?

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