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Mangosteen


Discovered:
Xanthones from the green fruit hulls of Garcinia mangostana.

Anti-leukemic:
2003 Aug Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
2004 Aug In vitro evaluation of antileukemic activity of 17 commonly used fruits and vegetables in Taiwan
2004 Nov Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.
2008 Apr Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.

AntiFungal:
Evaluation of the Antifungal Activity of Natural Xanthones from Garcinia mangostana and Their Synthetic Derivatives

AntiBacterial:
Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus.

Breast Cancer:
#1Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line.
#2Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line.

Neuroprotectant:
Antioxidative and neuroprotective activities of extracts from the fruit hull of mangosteen (Garcinia mangostana Linn.).

Fight MRSA:
Activity of medicinal plant extracts against hospital isolates of methicillin-resistant Staphylococcus aureus.

Antibiotic Synergism:
Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics.

Tuberculosis:
Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.

Acne:
#1 Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria.
#2 Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes.

Inflamation:
#1 Effect of mangostin, a xanthone from Garcinia mangostana Linn. in immunopathological & inflammatory reactions.
#2 inflammatory activity of mangostins from Garcinia mangostana.

AntiHistimine
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.

Heart Healthy:
Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats.

Extraction:
HPLC analysis of selected xanthones in mangosteen fruit.

Other Research
Sloan Kettering - Mechanism of Action
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