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Pomegranate


Synergistic Components:
2005 Jun In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
2005 Jan Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions

Prostate Cancer:
2006 Feb Prostate cancer prevention through pomegranate fruit.
2007 Sep Anti-oxidants from green tea and pomegranate for chemoprevention of prostate cancer

Lung Cancer:
2007 Jan Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice
2007 Apr Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice

Breast Cancer:
2002 Feb Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer
2004 Aug Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture

Pathways:
2005 Jan Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice
Book: Molecular Mechanisms of Chemoprevention of Cancer by Pomegranate
2005 Mar Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.

BioAvailability:
2004 Aug The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans
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