Supplements, Research, AML Herbal Regimen
Onions, Apples, Rutin, and Buckwheat Tea (Quercetin)
Targets Leukemic Cells:
Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors.
Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-beta 1 in these cells
Quercetin and the growth of leukemic progenitors.
Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia
Win-WNT pathway in ALL
Normal vs Leukemic:
Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination: role of heat-shock protein-70.
Flavonoid effects on normal and leukemic cells
How it works:
1992 (with chemo)
The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth.
2005 Feb (synergistically)
Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells
Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.
2007 Feb (anti/pro oxident)
Induction of apoptosis by quercetin: different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells.
2007 Jul (signaling cascades)
Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
2006 Dec Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
2006 Nov Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).
2004 May The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.
2008 Jun Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.
2007 Mar TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation.
Head and Neck Cancer:
2005 Sep Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer
Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.
Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B.
Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.
Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers.
Absorption and disposition kinetics of the dietary antioxidant quercetin in man.
Bioavailability of the dietary antioxidant flavonol quercetin in man.
Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man.
Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake.
Absorption and excretion of conjugated flavonols, including quercetin-4'-O-beta-glucoside and isorhamnetin-4'-O-beta-glucoside by human volunteers after the consumption of onions.
Pharmacokinetics and bioavailability of the flavonol quercetin in humans.
Absorption and antioxidant effects of quercetin from onions, in man.
Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers.
Various cooking methods and the flavonoid content in onion.
Pharmacokinetics and bioavailability of quercetin glycosides in humans.
Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.
Dietary flavonoids induce MLL translocations in primary human CD34+ cells
(caution for pregnant women)
Effects of Quercetin on the Pharmacokinetics of Etoposide after Oral or Intravenous Administration of Etoposide in Rats
Other Reviews / Interactions:
Papain and Bromelain:
May assist the absorption of Quercetin in the intestine.
Quinolone antibiotic: Quercetin may compete for DNA gyrase binding sites on bacteria