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Peer reviewed journal papers preferred (PubMed) see: Google Scholar
Other Resources: NCCAM Clinical Trial Directory, Complimentary Medicine Search
Evidence Based CAM, Oregon State University, Sloan Kettering, Creighton University, NCCAM Herbs, HerbMed, Sigma-Aldrich


Apoptosis, Review, Epigenetics, ROS Therapy, Blood-Brain, Cell Paths, Synergisms
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Onions, Apples, Rutin, and Buckwheat Tea (Quercetin)


Targets Leukemic Cells:
1991 Dec Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors.
1995 Jul Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-beta 1 in these cells
1996 Sep Quercetin and the growth of leukemic progenitors.
2007 Apr Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia
2007 Apr Win-WNT pathway in ALL

Normal vs Leukemic:
1997 Sep Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination: role of heat-shock protein-70.
2003 Jun Flavonoid effects on normal and leukemic cells

How it works:
1992 (with chemo) The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth.
2005 Feb (synergistically) Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells
2005 May Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.
2007 Feb (anti/pro oxident) Induction of apoptosis by quercetin: different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells.
2007 Jul (signaling cascades) Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention

Colon Cancer:
2006 Dec Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells

Liver Cancer:
2006 Nov Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).

Lung Cancer:
2004 May The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.

Prostate Cancer:
2008 Jun Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.
2007 Mar TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation.

Head and Neck Cancer:
2005 Sep Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer

Inflamation:
2004 Sep Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.
2004 May Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B.
2008 Mar Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.
2008 May Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.

BioAvailability:
1994 Dec Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers.
1996 Absorption and disposition kinetics of the dietary antioxidant quercetin in man.
1997 Mar Bioavailability of the dietary antioxidant flavonol quercetin in man.
1997 Nov Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man.
1998 Jul Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake.
1998 Sep Absorption and excretion of conjugated flavonols, including quercetin-4'-O-beta-glucoside and isorhamnetin-4'-O-beta-glucoside by human volunteers after the consumption of onions.
1999 May Pharmacokinetics and bioavailability of the flavonol quercetin in humans.
1999 Feb Absorption and antioxidant effects of quercetin from onions, in man.
2000 Nov Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers.
2001 Feb Various cooking methods and the flavonoid content in onion.
2001 May Pharmacokinetics and bioavailability of quercetin glycosides in humans.
2005 Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.

Warnings:
April 2007: Dietary flavonoids induce MLL translocations in primary human CD34+ cells
   (caution for pregnant women)
April 2009: Effects of Quercetin on the Pharmacokinetics of Etoposide after Oral or Intravenous Administration of Etoposide in Rats

Other Reviews / Interactions:
Sloan Kettering
      Papain and Bromelain: May assist the absorption of Quercetin in the intestine.
      Quinolone antibiotic: Quercetin may compete for DNA gyrase binding sites on bacteria
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