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Supplements, Research, AML Herbal Regimen


Peer reviewed journal papers preferred (PubMed) see: Google Scholar
Other Resources: NCCAM Clinical Trial Directory, Complimentary Medicine Search
Evidence Based CAM, Oregon State University, Sloan Kettering, Creighton University, NCCAM Herbs, HerbMed, Sigma-Aldrich


Apoptosis, Review, Epigenetics, ROS Therapy, Blood-Brain, Cell Paths, Synergisms
Delivery, Dose Logs, Disclaimer

Apples (procyanidins, catechin, epicatechin, chlorogenic acid, phloridzin, quercetin conjugates)


Apples AntiCancer:
2006 Feb Antitumor activities of apple extracts
2007 Sep Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3

Leukemia - synergy with ellagic acid and resveratrol (red raspberries, cranberries, and muscadine grapes)
2003 Aug Low Concentrations of Quercetin and Ellagic Acid Synergistically Influence Proliferation, Cytotoxicity and Apoptosis in MOLT-4 Human Leukemia Cells–

Colon Cancer:
2005 Mar Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis

Lung Cancer:
1997 Aug Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.
2000 Jan Intake of Flavonoids and Lung Cancer

Liver Cancer:
2000 Jun Nutrition: Antioxidant activity of fresh apples
2003 Jan Antioxidant activity of apple peels.

AntiOxident/AntiProlifarative/Neural Protectant:
2002 Jul Antioxidant and Antiproliferative Activities of Common Fruits
2006 May Apple Phenolics Protect in Vitro Oxidative Stress-induced Neuronal Cell Death

How it works:
2006 Effect of Apple Extracts on NF-B Activation in Human Umbilical Vein Endothelial Cells
2008 Aug Effect of 2alpha-Hydroxyursolic Acid on NF-kappaB Activation Induced by TNF-alpha in Human Breast Cancer MCF-7 Cells.

Best Type (Red Delicious) Best Part (Apple Peelings):
2001 Aug Antioxidant and antiproliferative activities of selected New York apple cultivars.
2007 May Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity.
Reviews:
2004 May Apple phytochemicals and their health benefits
2003 Mar Apple peels as a value-added food ingredient.
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