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Supplements, Research, AML Herbal Regimen

Peer reviewed journal papers preferred (PubMed) see: Google Scholar
Other Resources: NCCAM Clinical Trial Directory, Complimentary Medicine Search
Evidence Based CAM, Oregon State University, Sloan Kettering, Creighton University, NCCAM Herbs, HerbMed, Sigma-Aldrich

Apoptosis, Review, Epigenetics, ROS Therapy, Blood-Brain, Cell Paths, Synergisms
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Thunder of God Vine tripterygium wilfordii Hook. f. (Celastrol/Triptolide/Tripterine)
2002 Sep Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation.
2006 Jan Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.
2006 May Celastrol's Anticancer Mechanism Discovered
2007 Apr Blood: Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells...
2008 Jan A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
2008 Mar Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

Apoptotic Pathway Overview:
2005 May Targeting apoptosis pathways in cancer therapy.
2005 Targeting the IAP Family of Caspase Inhibitors as an Emerging Therapeutic Strategy.
2007 Aug Novel therapies targeting the apoptosis pathway for the treatment of acute myeloid leukemia.
2008 Feb [The role of the inhibitor of apoptosis protein (IAP) family in hematological malignancies]
2008 Jun Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.

Apoptotic Pathway Effect of Tripterygium Wilfordii:
1999 Mar [In vitro study on cellular and molecular mechanism of tripterine treating leukemic mast cells]
2001 Nov Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells.
2006 Jul Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.
2008 Apr Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.
2006 May Celastrol, a Triterpene Extracted from the Chinese "Thunder of God Vine," Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice
2008 Oct Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-kappaB pathways in human multiple myeloma cells.

Other Research: